Michael R Knowles Selected Research

Dyneins (Dynein)

1/2022	The role of SPAG1 in the assembly of axonemal dyneins in human airway epithelia.
1/2020	Mutation of CFAP57, a protein required for the asymmetric targeting of a subset of inner dynein arms in Chlamydomonas, causes primary ciliary dyskinesia.
8/2014	A new tool improves diagnostic test performance for transmission em evaluation of axonemal dynein arms.
10/2013	Mutations in SPAG1 cause primary ciliary dyskinesia associated with defective outer and inner dynein arms.
3/2013	Mutations in CCDC39 and CCDC40 are the major cause of primary ciliary dyskinesia with axonemal disorganization and absent inner dynein arms.
5/2012	Mutations of DNAH11 in patients with primary ciliary dyskinesia with normal ciliary ultrastructure.
12/2009	Deletions and point mutations of LRRC50 cause primary ciliary dyskinesia due to dynein arm defects.
7/2006	DNAH5 mutations are a common cause of primary ciliary dyskinesia with outer dynein arm defects.

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Michael R Knowles Research Topics

Disease

30	Cystic Fibrosis (Mucoviscidosis) 04/2022 - 05/2004
21	Lung Diseases (Lung Disease) 01/2022 - 10/2005
19	Ciliary Motility Disorders (Primary Ciliary Dyskinesia) 11/2022 - 07/2005
5	Inflammation (Inflammations) 01/2020 - 01/2007
5	Bronchiectasis 01/2020 - 05/2012
4	Infections 01/2020 - 07/2007
3	Meconium Ileus 01/2019 - 01/2012
3	Pseudomonas Infections 12/2017 - 06/2009
3	Liver Diseases (Liver Disease) 01/2016 - 09/2009
2	Inborn Genetic Diseases (Disease, Hereditary) 04/2022 - 11/2006
2	Infertility (Sterility) 01/2022 - 04/2010
2	Situs Inversus 01/2021 - 05/2012
2	Cri-du-Chat Syndrome (5p- Syndrome) 11/2018 - 10/2014
2	Pancreatic Diseases (Pancreatic Disease) 05/2015 - 04/2010
2	Intestinal Obstruction (Obstruction, Intestinal) 12/2012 - 01/2012
2	Persistent Infection 06/2009 - 07/2007
1	Insulin Resistance 01/2020
1	Type 2 Diabetes Mellitus (MODY) 01/2020
1	Hydrocephalus (Hydrocephaly) 11/2019
1	Ciliopathies 11/2019
1	Diffuse panbronchiolitis 01/2019
1	Deglutition Disorders (Dysphagia) 11/2018
1	Muscle Hypotonia (Hypotonia) 11/2018
1	Virus Diseases (Viral Diseases) 01/2018
1	Cough 01/2016
1	Fibrosis (Cirrhosis) 01/2016
1	Varicose Veins (Varicose Vein) 01/2016
1	Rare Diseases (Rare Disease) 10/2014
1	Bacterial Infections (Bacterial Infection) 04/2011
1	Male Infertility (Male Sterility) 11/2007
1	Cataract (Cataracts) 01/2006

Drug/Important Bio-Agent (IBA)

9	Proteins (Proteins, Gene)FDA Link 01/2020 - 05/2004
9	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 01/2020 - 10/2005
8	Dyneins (Dynein)IBA 01/2022 - 07/2006
7	Nitric Oxide (Nitrogen Monoxide)FDA Link 12/2021 - 05/2012
6	Biomarkers (Surrogate Marker)IBA 12/2016 - 05/2004
3	MucinsIBA 01/2020 - 01/2011
3	Amiloride (Midamor)FDA LinkGeneric 01/2006 - 01/2003
2	Axonemal DyneinsIBA 01/2022 - 07/2005
2	MacrolidesIBA 01/2019 - 12/2017
2	chenodeoxycholate sulfate conjugate (CDCS)IBA 11/2018 - 10/2014
2	Anti-Bacterial Agents (Antibiotics)IBA 12/2017 - 07/2007
2	Transforming Growth Factors (Transforming Growth Factor)IBA 10/2016 - 07/2011
2	Transcription Factors (Transcription Factor)IBA 12/2014 - 12/2012
2	AerosolsIBA 09/2014 - 09/2004
2	Sodium Chloride FDA LinkGeneric 04/2010 - 01/2006
2	Transforming Growth Factor beta1 (TGF beta 1)IBA 09/2009 - 11/2006
1	Phenobarbital (Luminal)FDA Link 04/2022
1	Immunoglobulin Km AllotypesIBA 11/2021
1	Immunoglobulins (Immunoglobulin)IBA 11/2021
1	AntigensIBA 11/2021
1	ivacaftorIBA 01/2021
1	Protein Kinases (Protein Kinase)IBA 01/2020
1	NIMA-Related KinasesIBA 01/2020
1	RNA (Ribonucleic Acid)IBA 01/2020
1	Amyloid (Amyloid Fibrils)IBA 01/2020
1	Erythromycin (Erycette)FDA LinkGeneric 01/2020
1	Forkhead Transcription Factors (Forkhead Box Proteins)IBA 11/2019
1	AngiotensinsIBA 01/2019
1	P-2 (P 2)IBA 01/2019
1	HLA Antigens (Human Leukocyte Antigens)IBA 01/2018
1	Tobramycin (Nebcin)FDA LinkGeneric 12/2017
1	Azithromycin (Zithromax)FDA LinkGeneric 12/2017
1	ChloridesIBA 12/2016
1	Transaminases (Aminotransferases)IBA 01/2016
1	Intergenic DNA (Junk DNA)IBA 01/2016
1	TrypsinogenIBA 05/2015
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 02/2015
1	methionine sulfoxideIBA 12/2012
1	TransferasesIBA 12/2012
1	Complement System Proteins (Complement)IBA 05/2012
1	Biological ProductsIBA 01/2012
1	Phospholipases (Phospholipase)IBA 04/2011
1	Interleukin-8 (Interleukin 8)IBA 04/2011
1	TitaniumIBA 03/2011
1	Messenger RNA (mRNA)IBA 03/2010
1	alpha 1-Antitrypsin (alpha 1 Antitrypsin)IBA 09/2009
1	Mannose-Binding Lectin (Mannan-Binding Lectin)IBA 09/2009
1	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 09/2009
1	Glutathione Transferase (Glutathione S-Transferase)IBA 09/2009
1	Interleukin-1 (Interleukin 1)IBA 06/2009
1	Blood Group Antigens (Blood Groups)IBA 01/2009
1	Nonsense Codon (Nonsense Mutation)IBA 07/2007
1	AminoglycosidesIBA 07/2007
1	CalciumIBA 01/2007
1	Calcium Carbonate (Limestone)FDA Link 01/2007
1	Genetic Markers (Genetic Marker)IBA 11/2006
1	prednylidene (Pred)IBA 10/2006
1	Codon (Codons)IBA 10/2005
1	Uridine Triphosphate (UTP)IBA 09/2004
1	SaltsIBA 09/2004
1	neodymium pyrocatechin disulfonate (NPD)IBA 08/2004
1	Blood Proteins (Serum Proteins)IBA 05/2004

Therapy/Procedure

7	Therapeutics 01/2019 - 05/2004
2	Lung Transplantation 01/2021 - 07/2007
2	Drug Therapy (Chemotherapy) 01/2020 - 12/2017
1	Length of Stay 11/2022
1	Precision Medicine 01/2019
1	Liver Transplantation 01/2016
1	Lenses 01/2006